Activating mutations of phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) gene confer sensitivity to PD-L1 checkpoint inhibition in metastatic adenocarcinoma patients
Altered oxidative stress was observed in patients with endometriosis ( 4.1 Oxidative stress and mitochondrial function Oxidative stress plays a key role in the pathogenesis of endometriosis-related infertility
Como Kubrick ao filmar em 1980 sua obra-prima O Iluminado, ele arranca daqueles cenrios uma atmosfera que assusta sem precisar de quase nada, alm de um corredor, enquanto a trilha sonora opera sua magia
Three different tests: Tendon outgrowth , how many cells grow out from a piece of tendon in the dish Wound healing assay , cells are grown as a monolayer, you make a scratch in it and observe how quickly it closes Cell survival , you add peroxide (oxidative stress, which normally kills cells) and observe how many survive What they found: Tenocytes grew faster and in a dose-dependent curve (the more BPC-157, the more growth) The scratch closed 1.8 faster at 1 g/ml BPC-157 Under oxidative stress, 22 % of cells survived without BPC-157, but 67 % with BPC-157 When they blocked the FAK enzyme, the effect disappeared mechanism confirmed Why it matters: This is not just a systemic effect via blood, BPC-157 directly modifies the biology of an individual cell
